8/30 9:15 - 11:45, Hewlett 103
Robustness in Biochemical Circuits: a Reaction Network Theory Approach
Guy Shinar1, Uri Alon1 and Martin Feinberg2
1.Department of Molecular Cell Biology and Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel. 2.William G. Lowrie Department of Chemical & Biomolecular Engineering and Department of Mathematics, Ohio State University, 125 Koffolt Laboratories, 140 W. 19th Avenue, Columbus, OH 43210.
Summary One of the central tenets of systems biology is the principal of robustness, which asserts that biochemical circuits have evolved to maintain their function even in the face of large environmental disruption [1, 2]. Because the function of biochemical circuits often depends on the steady state concentration of certain molecular species, it is important to understand the design principles that underlie concentration robustness.
Much has been learned about concentration robustness from the study of specific examples [3-7]. However, broad design principles that explain the structural sources of concentration robustness in large and important classes of biochemical reaction networks have largely remained elusive. Thanks to recent advances  in chemical reaction network theory [9-13], we are now closer to understanding how robustness may arise from reaction network structure.
Organization The proposed tutorial is organized as two one-hour sessions. The purpose of the first session is to present the rudimentary concepts of chemical reaction network theory, in particular, those concepts that are important for deriving general results on robustness. The purpose of the second session is to show how these concepts are applied to obtain two general results: a necessary condition for approximate concentration robustness in the very large class that includes all detailed balanced mass-action systems, and a sufficient condition for absolute robustness in a broad and relevant class of open systems. Examples of robust signaling and metabolic networks will be used throughout.
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Registration Registered attendees please register for this Tutorial.