Workshop 3

9/4 9:00 - 5:00, 380-380X

Systems Biology of Hypoxic Response and Angiogenesis

Amina Ann Qutub

Rice University.

Oxygen homeostasis determines our survival. Our integrated response to hypoxia shapes the progression of disease; how we develop and age; and how we adapt to our environment. Angiogenesis, the growth of capillaries from preexisting microvasculature, is a response to hypoxic conditions associated with numerous pathologies including cancer, ischemia, peripheral artery disease, obesity and chronic inflammation.
This workshop highlights ways systems biology can elucidate the mechanisms underlying hypoxia and angiogenesis. Topics covered include coupling computational models with live imaging of the microvasculature, analyzing the modularity of hypoxic response gene and protein networks across cell types, and developing therapies that can be tested in silico. Featured speakers will come from the diverse fields of radiology, computational systems biology, neuropathology, developmental biology, bioengineering, oncology, and immunology - all with research interests that can be applied to understanding hypoxic response and angiogenesis.

9:00-9:10 Introduction

Session 1: Angiogenesis & hypoxia in disease
9:10-9:50 Amato Giaccia, Stanford University
9:50-10:30 Damir Janigro, Cleveland Clinic

10:30-10:40 Coffee Break

Session 2: Multiscale imaging & modeling of the microvasculature
10:40-11:20 Arvind Pathak, Johns Hopkins University
11:20-12:00 Amina Qutub, Rice University

12:00-1:30 Lunch

Session 3: Analyzing hypoxic response of stem cells
1:30-2:10 Fan Yang, Stanford University
2:10-2:50 Geoffrey Gurtner, Stanford University

2:50-3:00 Coffee Break

Session 4: Hypoxic gene regulation & metabolism; hypoxia, inflammation and angiogenesis
3:00-3:40 Nic Denko, Stanford University
3:40-4:20 Randall Johnson, University of California, San Diego

4:20-4:50 Roundtable/Panel Discussion

4:50-5:00 Wrap-up

Registration Registered attendees please register for this Workshop.