Plenary 5.1

9/2 8:00 - 10:30, Memorial Auditorium

Basal Dynamics of p53 in Single Cells

Galit Lahav

Assistant Professor of Systems Biology, Harvard University.

Our lab is interested in understanding how the dynamic behavior of biological signals is controlled and how these dynamics affect cellular responses. We focus on the signaling pathway of the tumor suppressor protein p53, which is the protein most frequently inactivated in human cancer. Our single cell imaging studies showed that DNA damage initiates a series of p53 pulses that vary in number from cell to cell. We have recently discovered that p53 shows spontaneous pulses even in the absence of external damage. In this talk I will discuss the structure of the network that shapes p53's dynamical behavior in response to extrinsic and intrinsic damage and will describe possible functions of these dynamics.

Galit LahavGalit Lahav received her PhD in 2001 from the Department of Biology in the Technion, Israel Institute of Technology. Between the years 2001-2003, she completed her postdoctoral fellowship at the Weizmann Institute of Science in Israel. She then spent a year at Harvard's Bauer Center for Genomics Research and in the fall of 2004 was appointed as an Assistant Professor in the Department of Systems Biology at Harvard Medical School. Her lab combines experimental and theoretical approaches to study the dynamics of signaling networks in human cells as well as to understand cellular decision-making in individual cells.