Breakout 7.3

9/3 11:00 - 1:00, Hewlett 200

Metabolomes and data-driven systems biology

Masaru Tomita

Professor and the Director of Institute for Advanced Biosciences, Keio University.

We have developed a novel technology for high-throughput metabolome analysis based on capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS), which can quantify a large amount of cellular metabolites simultaneously. We have applied this technology to various fields of systems biology, including (1) biomarker discovery of hepatotoxicity, (2) hypoxia-induced metabolism of red blood cell, (3) multi-omics of E. coli single-gene-deletion mutants, and (4) cancer-specific energy metabolism in glucose limited conditions.

References

  1. J. Biol. Chem. 281: 16768-16776 (2006).
  2. J. Biol. Chem. 282: 10731-107341 (2007).
  3. Science 316, 593-597 (2007).
  4. Cancer Res. 69: 11, 4918-25 (2009).

Masaru TomitaMasaru Tomita is a Professor and the Director General of the Institute for Advanced Biosciences, Keio University. He received Ph.D. in Computer Science from Carnegie Mellon University (1985), Ph.D. in Electrical Engineering from Kyoto University (1994) and Ph.D. in Molecular Biology from Keio University (1998). He is a recipient of Presidential Young Investigators Award from National Science Foundation of USA (1988) and various other awards. His current research field includes Systems Biology, Metabolomics, and Computational Biology.