Breakout 9.1

9/3 11:00 - 1:00, Jordan Hall 420-040

Controlling Noisy Oscillators to Achieve Robust Timekeeping

Francis J. Doyle III

Professor of Chemical Engineering, University of California, Santa Barbara.

The generation of highly robust rhythms from the synchronization of large numbers of oscillators is is a recurring theme in biology. Of particular interest in this talk is the exquisite synchrony achieved in circadian oscillators in the brain, arising from a population of “sloppy” cellular timekeepers that are linked by local signaling cues. The details of the coupling mechanism will be presented, with an emphasis on phase metrics for modeling and analysis. Extensions of this work for other biological systems, including coral reproduction, will be outlined.

Francis J. DoyleDr. FRANCIS J. DOYLE III is the Associate Dean for Research in the College of Engineering at UC, Santa Barbara and he is the Associate Director of the Army Institute for Collaborative Biotechnologies. He holds the Duncan and Suzanne Mellichamp Chair in Process Control in the Department of Chemical Engineering, as well as appointments in the Electrical Engineering Department, and the Biomolecular Science and Engineering Program. He received his B.S.E. from Princeton (1985), C.P.G.S. from Cambridge (1986), and Ph.D. from Caltech (1991), all in Chemical Engineering. He is currently the editor-in-chief of the IEEE Transactions on Control Systems Technology, and holds Associate Editor positions with the Journal of Process Control, the SIAM Journal on Applied Dynamical Systems, and Royal Society's Interface. In 2005, he was awarded the Computing in Chemical Engineering Award from the American Institute of Chemical Engineers for his innovative work in systems biology. In 2008 he was appointed as a Fellow in IEEE, and in 2009, as a Fellow in IFAC. His research interests are in systems biology, network science, modeling and analysis of circadian rhythms, drug delivery for diabetes, model-based control, and control of particulate processes.