Breakout 9.3

9/3 11:00 - 1:00, Jordan Hall 420-040

Systems Biology of Mammalian Circadian Clocks

Hiroki R. Ueda

Team Leader, Laboratory for Systems Biology and Functional Genomics Unit, Center for Developmental Biology, RIKEN, Japan.

Mammalian circadian clock system is a complex and dynamic system consisting of complicatedly integrated regulatory loops and displaying the various dynamic behaviors including (i) endogenous oscillation with about 24-hour period, (ii) entrainment to the external environmental changes (temperature and light cycle), and (iii) temperature compensation over the wide range of temperature.

The logic of such biological networks such as circadian clocks is difficult to elucidate without (1) comprehensive identification of network structure, (2) prediction and validation based on quantitative measurement and perturbation of network behavior, and (3) design and implementation of artificial networks of identified structure and observed dynamics. In this symposium, we will report on the current progress in the analysis and synthesis of mammalian circadian clocks.


  1. Ueda, H.R. et al, Nature 418, 534-539 (2002).
  2. Ueda, H.R. et al, Nat. Genet. 37, 187-192 (2005).
  3. Sato T K, et al, Nat Genet. 38, 312-9 (2006).
  4. Ukai H, et al, Nat Cell Biol. 9, 1327-34 (2007).
  5. Ukai-Tadenuma M, et al, Nat Cell Biol. 10, 1154-63 (2008).

Hiroki R. UedaDr. Hiroki R. Ueda graduated from Medicine school in University of Tokyo in 2000, and obtained Ph.D there in 2004. While a graduate student, he was appointed as laboratory head at the CDB from 2003 and appointed as a manager of Functional Genomics Unit at the CDB from 2004. He also became a visiting professor in Tohoku University in 2005-2006, and Tokushima University from 2005, and an invited professor (biology) in Osaka University from 2006, and an invited professor (mathematics) in Kyoto University from 2009. His research interests include system-level understanding of biological time, space and information, and systems-based medicine on human disease.