Breakout Session 7 – HT Data Reconciliation
9/3 11:00 - 1:00, Hewlett 200
University of California, San Diego.
Metabolomes and data-driven systems biology
We have developed a novel technology for high-throughput metabolome analysis based on capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS), which can quantify a large amount of cellular metabolites simultaneously. We have applied this technology to various fields of systems biology, including (1) biomarker discovery of hepatotoxicity, (2) hypoxia-induced metabolism of red blood cell, (3) multi-omics of E. coli single-gene-deletion mutants, and (4) cancer-specific energy metabolism in glucose limited conditions.
- J. Biol. Chem. 281: 16768-16776 (2006).
- J. Biol. Chem. 282: 10731-107341 (2007).
- Science 316, 593-597 (2007).
- Cancer Res. 69: 11, 4918-25 (2009).
Dana Farber Cancer Instititute, Harvard University.