Breakout Session 9 – Circadian Rhythms

9/3 11:00 - 1:00, Jordan Hall 420-040

Breakout Session 9.1

Controlling Noisy Oscillators to Achieve Robust Timekeeping

Francis J. Doyle III

University of California, Santa Barbara.

The generation of highly robust rhythms from the synchronization of large numbers of oscillators is is a recurring theme in biology. Of particular interest in this talk is the exquisite synchrony achieved in circadian oscillators in the brain, arising from a population of “sloppy” cellular timekeepers that are linked by local signaling cues. The details of the coupling mechanism will be presented, with an emphasis on phase metrics for modeling and analysis. Extensions of this work for other biological systems, including coral reproduction, will be outlined.

Breakout Session 9.2

Jay C. Dunlap

Dartmouth University.

Breakout Session 9.3

Systems Biology of Mammalian Circadian Clocks

Hiroki R. Ueda

Center for Developmental Biology, RIKEN, Japan.

Mammalian circadian clock system is a complex and dynamic system consisting of complicatedly integrated regulatory loops and displaying the various dynamic behaviors including (i) endogenous oscillation with about 24-hour period, (ii) entrainment to the external environmental changes (temperature and light cycle), and (iii) temperature compensation over the wide range of temperature.

The logic of such biological networks such as circadian clocks is difficult to elucidate without (1) comprehensive identification of network structure, (2) prediction and validation based on quantitative measurement and perturbation of network behavior, and (3) design and implementation of artificial networks of identified structure and observed dynamics. In this symposium, we will report on the current progress in the analysis and synthesis of mammalian circadian clocks.

References

  1. Ueda, H.R. et al, Nature 418, 534-539 (2002).
  2. Ueda, H.R. et al, Nat. Genet. 37, 187-192 (2005).
  3. Sato T K, et al, Nat Genet. 38, 312-9 (2006).
  4. Ukai H, et al, Nat Cell Biol. 9, 1327-34 (2007).
  5. Ukai-Tadenuma M, et al, Nat Cell Biol. 10, 1154-63 (2008).