Plenary Session 6 – Dynamics
9/2 4:00 - 6:00, Memorial Auditorium
Michael B. Elowitz
California Institute of Technology.
Evolutionary Dynamics and Biological Disorganization
Daniel S. Fisher
Protein localization is important for bacterial cell-cycle regulation?
Kerwyn C. Huang
In this talk, I will describe how pole-to-pole oscillations of the Min-protein system help to regulate cell division in E. coli. We have developed a model of the Min system which accurately reproduces the observed oscillations in rod-shaped, round, and branched cells. These results suggest that oscillations may provide a general mechanism by which proteins can localize in response to features of cell geometry. As a counterpoint to the importance of spatial localization in the Min system, I will also present evidence that misclocalization of the cell-cycle control system in Caulobacter crescentus can be corrected for by overexpression, suggesting that localization may have evolved via selection for efficiency.
Alexander van Oudenaarden
Massachusetts Institute of Technology.